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Magnetic Nanoparticle Detection and Separation by Magnetic Relaxation Time

机译:磁性弛豫时间检测和分离磁性纳米粒子

摘要

Wearable devices configured to detect the presence, concentration, number, or other properties of nanoparticles disposed in subsurface vasculature of a person are provided. The wearable devices are configured to magnetize the nanoparticles at an upstream location of subsurface vasculature and to detect, using a magnetometer, magnetic fields produced by the magnetized nanoparticles at a downstream location of subsurface vasculature. In some embodiments, the nanoparticles are configured to bind to an analyte of interest and detected properties of the magnetized nanoparticles can be used to determine the presence, concentration, or other properties of the analyte. Detecting magnetic fields produced by the magnetized nanoparticles can include detecting the fields directly, detecting an effect of the magnetic fields on nuclear magnetic spins of atoms proximate the magnetized nanoparticles, producing a time-varying magnetic field and detecting a time-varying magnetic field responsively produced by the magnetized nanoparticles, or some other method(s).
机译:提供了可穿戴装置,该可穿戴装置被配置为检测设置在人的地下脉管系统中的纳米粒子的存在,浓度,数量或其他性质。可穿戴设备被配置为在地下脉管系统的上游位置磁化纳米颗粒,并使用磁力计检测在地下脉管系统的下游位置由磁化的纳米颗粒产生的磁场。在一些实施方案中,纳米颗粒被配置为结合感兴趣的分析物,并且被磁化的纳米颗粒的检测特性可以用于确定分析物的存在,浓度或其他特性。检测由磁化的纳米颗粒产生的磁场可以包括直接检测磁场,检测磁场对靠近磁化的纳米颗粒的原子的核磁自旋的影响,产生随时间变化的磁场以及检测响应地产生的随时间变化的磁场。通过磁化的纳米颗粒,或其他一些方法。

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