piperazine 1,2-a indol-1-one and 1,4 diazepino 1,2-a indol-1-one

摘要

patent summary: "piperazine [1,2-a] indol-1-one and [1,4] diazepino [1,2-a] indol-1-one". The present invention relates to compounds of Formula II wherein R1, R2, R3 and X are as defined in the specification, or a pharmaceutically acceptable acid addition salt, racemic mixture or corresponding enantiomer thereof and / or optical isomers thereof for use as therapeutic active substances in the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorder, anxiety disorder, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, disorder post-traumatic stress disorder, panic disorder, parkinson's disease, dementia, alzheimer's disease, cognitive impairment, chemotherapy-induced cognitive dysfunction, down syndrome, autistic spectrum disorder, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis , multiple sclerosis, huntington's disease, stroke brain, radiation therapy, chronic stress, neuroactive drug abuse such as alcohol, opiates, methamphetamine, phencyclidine and cocaine, as well as its manufacturing process, pharmaceutical composition and use in the preparation of a drug.