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GUANIDINE COMPOUNDS USEFUL FOR PREVENTING AND/OR TREATING DIABETIC NEPHROPATHY OR DIABETIC MACULAR EDEMA

机译：适用于预防和/或治疗糖尿病性肾病或糖尿病性黄斑水肿的胍基化合物

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摘要

The present invention relates to 2-fluoro-3-(azetidin-1-yl)benzylcarbamimidoylcarbamate derivatives useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases. The present inventors have conducted intensive studies on a compound having a VAP-1 inhibitory activity, and as a result, they have found that the compound or a salt thereof of the present invention exhibits an excellent VAP-1 inhibitory activity and is useful for preventing and/or treating VAP-1-related diseases, in particular, diabetic nephropathy or diabetic macular edema, thereby completing the present invention. In addition, the present invention relates to a pharmaceutical composition, in particular, a pharmaceutical composition for preventing and/or treating VAP-1-related diseases, which comprises the compound or a salt thereof of the present invention, and an excipient.

机译：本发明涉及用作药物组合物，特别是预防和/或治疗VAP-1相关疾病的药物组合物的活性成分的2-氟-3-（氮杂环丁烷-1-基）苄基氨基甲酰氨基甲酸酯衍生物。本发明人对具有VAP-1抑制活性的化合物进行了深入研究，结果，他们发现本发明的化合物或其盐表现出优异的VAP-1抑制活性，并且可用于预防和/或治疗与VAP-1相关的疾病，特别是糖尿病性肾病或糖尿病性黄斑水肿，从而完成了本发明。另外，本发明涉及药物组合物，特别是用于预防和/或治疗VAP-1相关疾病的药物组合物，其包含本发明的化合物或其盐和赋形剂。

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公开/公告号EA025839B1

专利类型
公开/公告日2017-02-28

原文格式PDF
申请/专利权人 ASTELLAS PHARMA INC.;
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申请/专利号EA20150000448
发明设计人 KOUSEI;DAISUKE;SUSUMU;HIROYOSHI;HISASHI;NORIO;
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申请日2012-03-13
分类号C07D205/04;A61K31/426;A61K31/4402;A61K31/4545;A61K31/495;A61K31/496;A61K31/505;A61K31/506;A61K31/5377;A61K31/551;A61P1/02;A61P1/04;A61P1/16;A61P3/04;A61P3/10;A61P9;A61P9/10;A61P9/12;A61P11;A61P11/06;A61P13/12;A61P17;A61P17/04;A61P17/06;A61P19/02;A61P19/06;A61P21;A61P25;A61P25/04;A61P25/28;A61P27/02;A61P29;A61P37;A61P37/02;A61P37/06;A61P43;C07D211/26;C07D211/46;C07D211/56;C07D211/58;C07D211/62;C07D213/38;C07D213/74;C07D213/79;C07D213/80;C07D213/81;C07D217/06;C07D217/22;C07D237/20;C07D239/34;C07D239/42;C07D239/48;C07D241/04;C07D241/20;C07D243/08;C07D277/20;C07D277/42;C07D277/44;C07D277/46;C07D277/56;C07D277/62;C07D295/08;C07D295/18;C07D295/20;C07D295/22;C07D307/24;C07D309/04;C07D309/06;C07D309/08;C07D309/14;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D403/14;C07D405/04;C07D405/06;C07D405/12;C07D405/14;C07D409/12;C07D413/04;C07D413/12;C07D413/14;C07D417/12;C07D471/04;C07D471/10;C07D487/04;C07D487/08;C07D487/10;C07D495/04;C07D513/04;
国家 EA
入库时间 2022-08-21 13:39:16

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