CELL MODEL FOR EWING'S SARCOMA FAMILY OF TUMORS, AND ANTITUMOR AGENT SCREENING METHOD USING SAME

摘要

In order to address the problem of establishing a cell model for the Ewing's sarcoma family of tumors that reacts directly with chimeric genes to form tumors and can be used in screening for an effective, novel anticarcinogen for the Ewing's sarcoma family of tumors, the present invention provides an Ewing's sarcoma family of tumors (ESFT) cell derived from bone marrow stromal cells, wherein an EWS chimeric gene controlled by a promoter that includes an inducible transcriptional regulatory sequence is introduced into a chromosome, and the ESFT cell is viable and has unlimited proliferative capacity during expression of the EWS chimeric protein.