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BIOLOGICAL METHODS FOR DIAGNOSING ACTIVE TUBERCULOSIS OR FOR DETERMINING THE RISK OF A LATENT TUBERCULOSIS INFECTION PROGRESSING TO ACTIVE TUBERCULOSIS AND MATERIALS FOR USE THEREIN
BIOLOGICAL METHODS FOR DIAGNOSING ACTIVE TUBERCULOSIS OR FOR DETERMINING THE RISK OF A LATENT TUBERCULOSIS INFECTION PROGRESSING TO ACTIVE TUBERCULOSIS AND MATERIALS FOR USE THEREIN
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机译:诊断活动性结核病或确定正在进行的活动性结核病的潜伏性结核感染风险的生物学方法及所用材料
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摘要
There is provided methods for diagnosing active tuberculosis (ATB), or for determining the risk of a latent tuberculosis infection (LTBI) progressing to ATB, in an individual comprising or consisting of the steps of: a) providing a sample to be tested from the individual; b) measuring the expression in the test sample of GBP6 and/or BATF2; wherein the expression in the test sample of GBP6 and/or BATF2 is indicative of the presence of active tuberculosis (ATB) in the individual, and/or wherein the expression in the test sample of GBP6 and/or BATF2 is proportional to the risk of a latent TB infection progressing to an active TB infection in the individual. There are also provided binding agents and kits for use in such methods.
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