COMPOSITION FOR INDUCING DIFFERENTIATION FROM NEURAL STEM CELL INTO DOPAMINERGIC NEURON AND METHOD FOR DIFFERENTIATING FROM NEURAL STEM CELL INTO DOPAMINERGIC NEURON USING SAME

摘要

The present invention relates to a composition for inducing differentiation from nerve cell into dopaminergic neuron, containing a compound (also known as AS703026) which is a MEK1/2 inhibitor and is represented by chemical formula 1. The present invention further relates to a differentiation method using the same. The dopaminergic neuron differentiated from the neural stem cell using the composition can be applied to gene therapy or cell replacement therapy for treating neurodegenerative disease such as Parkinson′s disease. In addition, the dopaminergic neuron of the present invention gives a wide range of applications to be used as materials for various investigation or tests for drug effects in the development of new drug.;COPYRIGHT KIPO 2016