N- A lipophilic drug-loaded solid lipid nanoparticle surface-modified with N-trimethyl chitosan graft palmitic acid

摘要

The present invention relates to a lipid-soluble drug-containing solid lipid, which is surface-modified with an N-trimethylolchitosan bond-containing palmitic acid polymer, which comprises obtaining and mixing lipid-soluble drug-containing solid lipid nanoparticles The present invention relates to a method for producing nanoparticles, a lipid-soluble drug-containing solid lipid nanoparticle surface-modified with N-trimethylol chitosan-bound palmitic acid polymer prepared by the above method, and a preparation for oral administration of resveratrol in which resveratrol is encapsulated in the nanoparticles. The solid lipid nanoparticles encapsulated with the liposoluble drug of the present invention and surface-modified with the N-trimethylolchitosan bond-containing palmitic acid polymer are stable in an acidic gastric environment due to the coating of the polymer, so that even when orally administered, Release of the lipid-soluble drug, and thus the lipid-soluble drug can be effectively used as a preparation for oral administration of the lipid-soluble drug.;