method for determining the presence of a tumor in vitro, method for determining the state of tumor transformation, tm9sf4-positive extracellular vesicles and kit for use in determining the presence of a tumor or state of tumor transformation

摘要

The present invention relates to extracellular microvesicle biomarkers for determining tumor transformation status or the presence of a tumor in an individual, and the uses of such biomarkers and diagnostic methods using such biomarkers. in particular, the methods and uses of the present invention involve the isolation of tm9sf4-positive extracellular vesicles and the detection of expression of a second biomarker, preferably selected from the group consisting of cd9, mir-21 and rnu6 protein.