PYRIDINE AND PYRAZINE DERIVATIVES FOR THE TREATMENT OF AN INFLAMMATORY OR OBSTRUCTIVE AIRWAYS DISEASE OR CF (CYSTIC FIBROSIS)

摘要

The application describes pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.