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INHIBITOR OF SIRT1 EXPRESSION IN KERATINOCYTE AND METHOD OF INHIBITING SIRT1 EXPRESSION USING SAME
INHIBITOR OF SIRT1 EXPRESSION IN KERATINOCYTE AND METHOD OF INHIBITING SIRT1 EXPRESSION USING SAME
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机译：抑制角膜细胞中SIRT1表达的方法及使用相同方法抑制SIRT1表达的方法
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摘要
The present invention relates to a composition for inhibiting SIRT1 expression of human keratinocyte (pHEK), which inhibits the expression of SIRT1 in in vitro-cultured keratinocytes derived from the human skin, and thus can be actively used in researches for carrying out basic human skin research. The composition for inhibiting SIRT1 expression of human keratinocyte comprises at least one selected from the group consisting of antisense nucleotides, siRNA, and shRNA complementarily binding to mRNA of the SIRT1 (sirtruin-1) gene consisting of the nucleotide sequence of SEQ ID NO: 1.;COPYRIGHT KIPO 2018
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机译：本发明涉及用于抑制人角质形成细胞（pHEK）的SIRT1表达的组合物，该组合物在源自人皮肤的体外培养的角质形成细胞中抑制SIRT1的表达，因此可以积极地用于进行基本人皮肤的研究中。研究。抑制人角质形成细胞的SIRT1表达的组合物包含选自与由SEQ ID NO：1的核苷酸序列组成的SIRT1（sirtruin-1）基因的mRNA互补结合的反义核苷酸，siRNA和shRNA中的至少一种。 。; COPYRIGHT KIPO 2018
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