A method for evaluating the drug sensitivity of Mycobacnerium tuberculosis based on the results of determining immunological parameters of blood in a patient with pulmonary tuberculosis

摘要

FIELD: medicine.SUBSTANCE: method for assessment of Mycobacterium tuberculosis medicinal sensitivity of based on the results of blood immunological indices determination in a patient with pulmonary tuberculosis includes a blood test in which the absolute amount of phagocytic granulocytes and T lymphocytes expressing the HLA-DR-Ag late activation marker is established. The results are calculated by the formula Y=1.76-5.08X1-0.17X2, where X1 is CD3HLA-DR(10/liter), X2 is the number of phagocytic granulocytes (10/liter). At a value of Y1, a conclusion is made about the medicine-sensitive isolates of the tuberculosis causative agent, and at Y≥1 - about isolates without medicinal sensibility.EFFECT: application of this invention allows to assess Mycobacterium tuberculosis medicinal sensitivity without performing bacteriological tests, which reduces the variability of data between the test samples.4 ex