Drug delivery nanoparticles and treatments for drug resistant cancer

摘要

A composition comprising a nanoparticle comprising a carrier polypeptide and a double stranded oligonucleotide, wherein the carrier polypeptide comprises a cell targeting segment, a cell penetrating segment, and an oligonucleotide binding segment, wherein the carrier in the nanoparticle composition Disclosed herein are compositions and methods of making and using such nanoparticles, wherein the molar ratio of polypeptide to double stranded oligonucleotide is less than about 6: 1. Furthermore, a method of treating a subject having a cancer, such as a chemotherapeutic drug resistant cancer, comprising administering to the subject a composition comprising the nanoparticle, the nanoparticle comprising a cell targeting segment, a cell penetrating segment And a carrier polypeptide comprising an oligonucleotide binding segment; a double stranded oligonucleotide conjugated to the oligonucleotide binding segment; and a chemotherapeutic agent conjugated to the double stranded oligonucleotide. Also described are pharmaceutical compositions, articles of manufacture and kits comprising the described nanoparticles. [Selected figure] Figure 2