Transportable elements mobilisation to improve genetic and epigenetic variability in a population

摘要

This is a method for mobilising a transposable element. (a) provide a methylation inhibitor of DNA and /or a transcription inhibitor;And b) put in contact the inhibitor (or inhibitors) with a cell comprising inactive transposable elements,Producing a cell with transposable elements mobilized. In a second aspect of the invention,A method is provided to increase genetic and /or epigenetic variation in a plurality of eukaryotic organisms. The method comprises steps of I. Providing a methylation inhibitor of DNA and /or a transcription inhibitor,II. Put the organism in contact with the inhibitor (or inhibitors) and III. Propagate the organism.