ph-sensitive drug dispensing particles, composition, vial, device for parenteral administration, use of a plurality of particles or composition, methods for obtaining an immune response, treatment or prophylaxis, to prevent or reduce the interaction between a biologically active charge and components of an aqueous environment, to produce a plurality of drug dispensing particles and to produce a composition, and, vaccine.

摘要

The present invention relates to drug dispensing particles which may prevent the interaction between a biologically active charge comprised in the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to ph, so that above a threshold ph level the biologically active charge becomes accessible to the surrounding environment. such particles are therefore useful for stably storing a biologically active charge in an aqueous composition containing components that would otherwise detrimentally interact with the charge, and releasing the charge to mediate a biological effect on an animal's body, such as as a human, to whom the composition is administered. Compositions comprising such particles are also provided, as well as methods for making and using such particles and compositions.