target-specific fusion polypeptide, dimeric fusion polypeptide, isolated nucleic acid, isolated nucleic acid pair, host cell, method for producing a fusion polypeptide, immunoconjugate, pharmaceutical formulation, fusion polypeptide and use of the fusion polypeptide

摘要

described herein is a circular fusion polypeptide comprising a first part of a binding domain, a second part of a binding domain and a spacing domain, wherein the spacing domain is a polypeptide and comprises at least 25 amino acid residues. , the first binding domain part is a polypeptide and is fused through a first n-terminal linker to the spacing domain, the second binding domain part is a polypeptide and is fused through a second c-terminal linker to the spacing domain spacing, the first binding domain part and the second binding domain part are associated with each other and form a binding site that specifically binds to a target.