15¿-hydroxy-osaterone acetate crystalline polymorphic form a, process for producing a 15¿-hydroxy-osaterone acetate crystalline polymorphic form and pharmaceutical composition

摘要

A crystalline polymorphic form of 15α-hydroxy-osaterone acetate is provided with proven stability (storage stability, spray stability and absorption characteristics). in a powder x-ray diffraction spectrum, the diffraction peaks characteristic of the crystalline polymorphic form a of 15α-hydroxy-osaterone acetate appear at the 2¿ diffraction angles of 9.6 ° ± 0.2 °, 17, 1 ° ± 0.2 ° and 20.2 ° ± 0.2 °. the crystalline polymorphic form a has a melting point of 280 to 283 ° C and is a prismatic crystal.