pharmaceutical composition, crystalline form of the bendamustine free base and method of treatment of chronic lymphocytic leukemia, hodgkin's disease, non-hodgkin's lymphoma, multiple myeloma or breast cancer

摘要

Novel polymorphic forms of bendamustine free base are described, including amorphous bendamustine free base, six anhydrous crystalline forms, four hydrate forms, and five solvate forms, with methods of their preparation and use also being described.