ANTI-INFLAMMATORY NON-SIALYLATED POLYPEPTIDE OF A MODIFIED hIgG1 Fc REGION, METHOD OF MAKING SAME AND USE THEREOF

摘要

The present invention relates to an isolated polypeptide comprising a modified sequence that is free of sialylation and is at least 75% identical to an hIgG1 Fc region sequence which is SEQ ID NO: 1 and is replaced with alanine or a conservative amino acid in position corresponding to an F241 sequence SEQ ID NO: 1 in accordance with Kabat numbering system, wherein the polypeptide has an anti-inflammatory activity that is higher than that of a parent polypeptide comprising SEQ ID NO: 1. The present invention also relates to a method for making the claimed polypeptide, an anti-inflammatory composition comprising the claimed polypeptide, a method for treating an inflammatory disease comprising administering to a subject in need thereof a therapeutically effective amount of the claimed polypeptide.