METHOD FOR IDENTIFYING PATIENTS WITH A HIGHER RISK OF DEVELOPING SECONDARY DILATED CARDIOMYOPATHY ASSOCIATED WITH MUTATIONS IN THE LAMIN A/C GENE

摘要

The present invention relates to a signature of circulating miRNAs that allow patients with pathogenic mutations in the lamin A/C (LMNA) gene to be identified, said mutations being associated with dilated cardiomyopathy (DCM). This profile also allows differentiation between healthy subjects without pathogenic mutations and subjects who have pathogenic mutations but are still phenotypically negative for DCM, and between various aetiologies of the disease, idiopathic DCM and genetic DCM associated with mutations in the LMNA gene.