METHOD FOR PREDICTING EFFICACY OF ANTI-PD-1 ANTIBODY OR ANTI-PD-L1 ANTIBODY THERAPY, METHOD FOR EVALUATING CANCER GRADE, AND METHOD FOR ENHANCING EFFICACY OF ANTI-PD-1 ANTIBODY OR ANTI-PD-L1 ANTIBODY THERAPY

摘要

The purpose of the present invention is to provide a method for predicting the efficacy of anti-PD-1 antibody or anti-PD-L1 antibody therapy and a method for evaluating the grade of a cancer that are based on a novel biomarker. This method for predicting the efficacy of anti-PD-1 antibody or anti-PD-L1 antibody therapy on a subject includes a step for measuring the LAT1 expression level in a sample collected from the cancerous tissue of the subject, and a step for predicting the efficacy of anti-PD-1 antibody or anti-PD-L1 antibody therapy on the subject on the basis of the LAT1 expression level. The method for evaluating the grade of a cancer in a subject includes a step for using anti-LAT1 antibodies and anti-PD-L1 antibodies to stain a sample collected from the cancerous tissue of the subject, and a step for evaluating the grade of the cancer in the subject on the basis of the presence or absence of LAT1-positive and PD-L1-positive sites.