首页> 外国专利> Method for evaluating immunity and providing information on cancer development using differences in distribution of immune cells in peripheral blood of colorectal cancer patients and normal people, and diagnostic kit using the same

Method for evaluating immunity and providing information on cancer development using differences in distribution of immune cells in peripheral blood of colorectal cancer patients and normal people, and diagnostic kit using the same

机译:利用结直肠癌患者和正常人外周血中免疫细胞分布差异评估免疫力并提供癌症发展信息的方法以及使用该方法的诊断试剂盒

摘要

According to the present invention, a method for evaluating the immunity of peripheral blood using the difference in the distribution of immune cells in peripheral blood of a colorectal cancer patient and a normal person and using the same to provide information on the presence or absence of colorectal cancer, (A) peripheral blood immunity Classifying lymphocytes, monocytes, and granulocytes by analyzing the cellular size and wrinkles of the cells; (B) analyzing the distribution of immune cells in peripheral blood of cancer patients and normal persons by staining the markers of the three types of immune cells with at least one antibody combination; (C) determining a combination of differences in cancer markers and normal persons with statistically significant result values of the marker markers in the two cancer patients and normal populations so as to determine whether cancer has occurred; And (D) diagnosing the presence of colorectal cancer by measuring immunity per unit blood without counting natural killer cells using a flow cytometer or a cell counter using the label marker.
机译:根据本发明,使用大肠癌患者和正常人的外周血中免疫细胞分布的差异并利用其提供有关是否存在大肠癌的信息来评估外周血免疫性的方法。癌症,(A)通过分析细胞的大小和皱纹将淋巴细胞,单核细胞和粒细胞分类的外周血免疫力; (B)通过用至少一种抗体组合染色三种类型的免疫细胞的标志物来分析癌症患者和正常人外周血中免疫细胞的分布; (C)确定在两个癌症患者和正常人群中癌症标志物和正常人的差异的组合,其标志物的统计显着性结果值,以确定是否已经发生癌症; (D)通过测量每单位血液的免疫力来诊断大肠癌的存在,而无需使用流式细胞仪或使用标记标记的细胞计数器来计数自然杀伤细胞。

著录项

  • 公开/公告号KR102018006B1

    专利类型

  • 公开/公告日2019-09-04

    原文格式PDF

  • 申请/专利权人 이종균;

    申请/专利号KR1020187002390

  • 发明设计人 이종균;최중범;

    申请日2018-01-11

  • 分类号G01N33/574;G01N15/14;G01N33/569;G01N33/58;

  • 国家 KR

  • 入库时间 2022-08-21 11:47:50

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