Large-scale epigenomic reprogramming links anabolic glucose metabolism to distal metastasis during the progression of pancreatic cancer progression

摘要

The present invention includes detecting large organized heterochromatin lysine (K) -9 modified domains (LOCK) and large DNA hypomethylated blocks in a sample containing DNA from a subject with cancer, such as PDAC. The present invention relates to a target identification method for epigenetic reprogramming. The present invention also provides for the use of differentially expressed genes to identify metastatic propensity in primary tumors, which are genes in the tables herein, oxidative stress genes, EMT genes, immunology Selected from genetic response genes, DNA repair genes, glucose metabolism genes, oxPPP genes, and PGD genes. Furthermore, the present invention affects epigenetic changes, including inhibition of oxPPP, including analyzing a sample from a subject before and after contact with the agent or compound, and measuring the effect of the agent or compound on the epigenetic change. Methods for identifying agents or compounds for exerting are provided.