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Production of Immune-Response-Stimulating Aerosols By Non-Thermal Plasma Treatment Of Airborne Pathogens

机译:通过非热等离子体处理机载病原菌生产刺激免疫反应的气溶胶

摘要

Infectious diseases can be transmitted to humans, or between humans and animals, by airborne viruses and bacteria, known as infectious aerosols. Current protective measures that individuals can take to avoid inhaling such aerosols are either marginally effective (personal face masks) or impractical (self-contained breathing apparatuses). Building ventilation systems employing high-efficiency filters to prevent distribution of such aerosols suffer from high energy costs and high filter replacement costs. The development of conventional, intramuscularly administered vaccines takes months or years to produce enough doses to protect a population from a rapidly spreading infectious disease. Airborne viruses and bacteria have been shown to be completely inactivated when exposed to non-thermal plasmas. Results indicate the potential for sub-lethal exposures of airborne pathogens could render them unable to spark an infection in a host, but still retain the necessary surface proteins to cause an immune response in the host.
机译:传染病可以通过空气传播的病毒和细菌传播给人类,也可以在人与动物之间传播,即传染性气溶胶。个人目前可采取的避免吸入此类气溶胶的保护措施或多或少是有效的(个人口罩)或不实用的(自给式呼吸器)。采用高效过滤器防止这种气溶胶分布的建筑通风系统遭受高能量成本和高过滤器更换成本的困扰。常规的肌内注射疫苗的开发需要数月或数年才能产生足够的剂量,以保护人群免于迅速传播的传染病。空气传播的病毒和细菌暴露于非热等离子体中时,已被证明可以完全灭活。结果表明,潜在的空气传播病原体暴露可能使它们无法在宿主中引发感染,但仍保留必要的表面蛋白以在宿主中引起免疫反应。

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