hematopoietic stem cell, hematopoietic progenitor cell, myeloid / monocyte-compromised progenitor cell, macrophage or monocyte, tumor-associated antigen-specific t cell, immune checkpoint inhibitor, 1-methyl-tryptophan, combination of a point inhibitor of immune check and a specific t-cell for tumor-associated antigen, method for treating or preventing cancer, and population of hematopoietic stem cells, hematopoietic progenitor cells, myeloid / monocyte-compromised progenitor cells, macrophages or monocytes.

摘要

a hematopoietic stem cell (hsc), a hematopoietic stem cell (hpc) a myeloid / monocyte-compromised progenitor cell, a macrophage or a monocyte comprising a vector in which the vector comprises at least one target sequence mir-130a and / or mir -126 functionally linked to a nucleotide sequence encoding interferon-alpha (ifnalpha) for use in the treatment or prevention of cancer in a patient, in which hsc, hpc, the myeloid / monocyte-compromised progenitor cell, the macrophage or the monocyte is used in combination with an immune checkpoint inhibitor and / or a tumor-associated antigen-specific t cell (taa).