ISOLATED MONOCLONAL ANTIBODY OR ANTIGEN BINDING FRAGMENT OF THE SAME, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, HOSPITAL CELL, METHODS OF PREVENTING OR REDUCING LOSS OF THRESHOLDING THERAPY OR ALLERGIC REACTION AND TO INCREASE THE EFFECTIVENESS AND / OR SAFETY OF AN ALLERGEN-SPECIFIC IMMUNOTHERAPY SCHEME, AND USE OF THE PHARMACEUTICAL COMPOSITION

摘要

antibodies that bind phage allergens, phage-related allergens, birch pollen, bet v 1 or compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies are provided herein. according to certain modalities, antibodies are fully human monoclonal antibodies that bind to bet v 1. antibodies are useful for binding bet v 1 in vivo, thus preventing the allergen from binding to preformed ige on the surface of mast cells or basophils . in doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and / or basophils, improving the undesirable response to phage allergens in sensitized individuals.