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Method for diagnosing a disease by detecting circRNA in body fluids
Method for diagnosing a disease by detecting circRNA in body fluids
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机译:通过检测体液中circRNA诊断疾病的方法
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摘要
The present application relates to a method for diagnosing a disease of a subject, comprising the step of determining the presence or absence of one or more circular RNA (circRNA) in a sample of a bodily fluid of said subject; wherein the presence or absence of said one or more circRNA is indicative for the disease. In particular the application relates to a method for diagnosing the neurodegenerative disease, preferably Alzheimer's disease, in a subject comprises the steps of —determining the level of one or more circRNA in a sample of a bodily fluid of said subject; —comparing the determined level to a control level of said one or more circRNA; wherein differing levels between the determined and the control level are indicative for the disease. Furthermore, the application relates to means for detecting circRNAs being a biomarker for a neurodegenerative disease and kits and array comprising nucleic acid probes for detecting exon-exon junctions in a head to tail arrangement of these circRNAs.
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