Application of Clostridium difficile surface proteins, composition and its application, antibodies and method of diagnosing infections caused by Clostridium difficile

摘要

The invention consists of two immunoreactive surface proteins of Clostridium difficile: 71 kDa protein and peptidase M24. These proteins are identified by antibodies present in the serum of the patient during Clostridium difficile infection. The invention also includes polynucleotides encoding these proteins, expression vectors, protein fragments and modifications, as well as compositions containing these proteins. The invention also involves the use of composition and antibodies directed at the immunoreactive surface protein Clostridium difficile 71 kDa and the diagnosis of Clostridium difficile infections.