FE^3+/2+-NO DONOR MIXED-VALENCE COORDINATION POLYMER AND APPLICATION THEREOF

摘要

Disclosed by the present invention is an Fe^3+/2+-NO donor mixed-valence coordination polymer Fe^x+₄(BPDB) (H₂O)₂; in the molecular formula, Fe^x+ represents Fe³⁺ and Fe²⁺, and BPDB is an NO donor:1,5-bis (L-proline azo-O²-)-2,4-dinitrobenzene. Further provided by the present invention are nanoparticles of the Fe^3+/2+-NO donor mixed-valence coordination polymer, the nanoparticles having higher water solubility and stability, and being capable of passively targeting tumors by means of the enhanced permeability and retention effect (EPR effect) of solid tumors. In response to high concentrations of GSH and high concentrations of H₂O₂ in a tumor microenvironment, NO is released and ROS is generated to achieve the efficient, low-toxicity, and synergistic treatment of tumors.