MALDI-TOF A high-throughput disease diagnostic system by fingerprinting of blood protein and metabolome based on MALDI-TOF mass spectrometry

摘要

The present invention relates to an ultrafast disease diagnosis system using blood protein and metabolite fingerprinting based on MALDI-TOF mass spectrometry, and according to the present invention, blood protein and metabolite fingerprinting based on MALDI-TOF mass spectrometry. The analysis enables a significant time reduction and mass analysis of the disease diagnosis, and the diagnosis method through the blood analysis is less costly and timely, and the patient's objection to the diagnosis is eased and the disease diagnosis is easy to access. In addition, by comparing and analyzing the diagnosis result by extracting the metabolite in the blood and building the database and the diagnosis result using the protein-based database in the blood, the diagnosis with high accuracy and reliability is possible by double checking. In addition, the present invention is a database-based diagnostic method that can be applied to a variety of diseases, the scalability of the technology is good, and socially effective people can be secured by barcoded human health status by establishing a mass analysis barcode database of blood analysis It can contribute to health care. In addition, as a diagnostic method that can be performed through a simple education rather than a conventional diagnostic method requiring a skilled expert, the entry barrier of the technology is low, there is a strong impact of the technology.