Machine for chemical analysis, including a combination of liquid chromatography and electron ionization mass spectrometry

摘要

The machine for chemical analysis (1) includes liquid chromatography (2), an electron ionization mass spectrometer (3), and a liquid chromatography (2) and an electron ionization mass spectrometer (with chromatographic nanocolumns having an inner diameter of 100 μm or less). 3) It includes a coupling assembly (4) interposed between. The coupling assembly 4 is housed inside a vaporized microcannula 10 with an inert gas flow and a first end 9a directly connected to the outlet end of the nanocolum 7 to receive a liquid phase with an internal diameter of 50 μm or less It comprises a microcapillary 8 having a second end 9b. The vaporized microcannula 10 partially engages the microcapillary 8 and has an end 15 facing the interior of the ionization chamber of the electron ionization mass spectrometer 3. The vaporized microcannula 10 is divided into a first portion 10a under the action of the heater 16 and a second portion 10b maintained at room temperature and having a length of 2 cm or more. The microcapillaries 8 occupy the entire interior of the second portion 10b of the vaporized microcannula 10 and have an end portion 8a arranged inside the first portion 10a and having a length of 5 mm or less.