Antalya Public Health Center of Ministry of Health, Antalya, Central Laboratories of Antalya Training and Research Hospital of Ministry of Health, Antalya, Akdeniz University Medical Faculty, Department of Biology Genetics, Antalya

摘要

Objective: Second-trimester maternal serum screening hasudbecome a routine part of prenatal care. We aimed to identifyudif triple test measurements were affected by regionaluddifferences and maternal factors. We compared our resultsudwith the results of a previous study on Turkish population,udand with the values of the manufacturer firm.udMaterial and Methods: The study group consisted of 984udpregnant women between 14–22 weeks of gestation whoudhad undergone a triple test. The original PRISCA softwareudwas used for calculating the statistical risk.udResults: Comparison of median values for serum AFP, betweenudpublished Turkish population, manufacturer valuesudand Gaziantep population were: 1% between Gaziantepudpopulation and Turkish population, and 3 % between Gaziantepudpopulation and manufacturer values in 16. gestationaludweek; 5 % and 4 % in 17. gestational week; 13 % and 14ud% in 18. gestational week, respectively. 19. gestationaludweek showed no difference. Same comparison for β-hCGudshowed; 5 % and 1 % in 16. gestational week; 4 % and 2 %udin 17. gestational week; 13 % and 1 % in 18. gestationaludweek; 1 % and 24 % in 19. gestational week, respectively.udComparison for uE3 values showed; 36 % and 95 % in 16.udgestational week; 39 % and 89 % in 17. gestational week; 25ud% and 67 % in 18. gestational week; 34 % and 72 % in 19.udgestational week, respectively.udConclusion: This study showed that, screening tests mayudvary based on regional differences. Our study presents audpotential risk factor that may be an explanation for someudproblems with the triple test evaluations in some laboratories.