Combined use of furosemide with selective and nonselective B-adrenergic antagonists for treatment of edematous syndrome associated with chronic circulatory failure in rats

摘要

Nowadays, a viewpoint about the increased activity of renin-angiotensin and sympathoadrenal systems in patients with edematous syndrome due to circulatory failure is generally accepted. Activation of these humoral systems in case of congestive heart failure and in cases of number of other cardiovascular diseases causes homeostatic reaction of kidneys which accompanied by the increase of sodium reabsorption in nephron and water retention in organism. This effect partly is result of stimulation of β-adrenergic receptors of renal tubules and of juxtaglomerular cells producing renin. Therefore, it is possible that β-adrenergic antagonists can cause in such conditions diuretic and natriuretic reactions which may be used for correction of water and electrolyte disturbances in diseases accompanied by increased activity of sympathoadrenal system.When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35799