NIOSH Skin Notation Profiles: 2-Mercaptobenzothiazole, Sodium 2-Mercaptobenzothiazole, Zinc 2-Mercaptobenzothiazole

摘要

This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with MBT, sodium MBT, and zinc MBT, in addition to (2) the rationale behind the hazard-specific skin notation (SK) assignments for MBT, sodium MBT, and zinc MBT. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations (NIOSH 2009). The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to MBT, sodium MBT, and zinc MBT. A literature search was conducted through April 2014 to identify information on MBT, sodium MBT, and zinc MBT, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to MBT, sodium MBT, and zinc MBT.