In Vitro Microbial Mutagenicity Studies of P-nitrophenol with Attachments and Cover Sheet dated 061289.

摘要

The mutagenicity of p-nitrophenol was evaluated in Salmonella tester strains TA1535, TA1537, and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at concentrations of 0, 10, 25, 50, 100, 200, 300, 400, and 500 ug/plate using the direct plate incorporation method. p-Nitrophenol did not cause a reproducible positive response in any of the bacterial tester strains, either in the presence or absence of added metabolic activation.