REDUCED RED CELL 2, 3-DIPHOSPKOGLYCERATE AND ADENOSINE TRIPHOSPHATE, HYPOPHOSPHATEMIA AND INCREASED HEMOGLOBIN-OXYGEN AFFINITY AFTER CARDIAC SURGERY Increased Hemoglobin-Oxygen Affinity After Cardiac Surgery 'Heraoglobin-Oxygen Affinity'

摘要

Serum inorganic phosphorous was decreased significantly on the third postoperative day following cardiac surgery in 18 patients initially studied. Reduced plasma inorganic phosphate has been shown to cause a reduced concen¬tration of red cell organic phosphates, an important determinant of hemoglobin oxygen affinity. Therefore, 10 consecutive patients were studied to determine if reduced 2,3 diphosphoglycerate (DPG) and adenosine triphosphate (ATPCon¬centration and increased hemoglobin-oxygen affinity accompained the fall in serum inorganic phosphate concentration.nA significant fall in 2,3-DPG and an increase in hemoglobin-oxygen affinity was present in red cells of patients studied on the first post-operative day. A reduction in red cell ATP was also present which per¬sisted for 5 days during which time red cell 2,3-DPG returned to levels which were in excess of preoperative values. The reduction in serum inorganic phosphorous followed the reduction in red cell 2,3-DPG and correlated with the reduction in ATP.