Neuroprotective Effects of HU-211 on Brain Damage Resulting from Soman- induced Seizures

摘要

The neuroprotective effects of HU-211 on soman-induced, seizure- related brain damage were examined in rats challenged with 180 %microngram/kg soman (i.e., 1.6 LD50) and treated with an intraperitoneal injection of 25 mg/kg HU-211 at 5 or 40 min following seizure onset. HU-211 had no effect on seizure strength or duration. Nevertheless, temporal lobe necrosis was significantly reduced at both 5 min and 40 min (76 and 72 % respectively), indicating that HU- 211 provides neuroprotection against soman-induced brain damage despite having no apparent effect on the seizures themselves. Future studies will examine the combined neuroprotective effects of HU-211 and diazepam.