Systematic Reviews of Randomized Controlled Trials of Chemotherapy and Endocrine Therapy in Advanced Breast Cancer

摘要

To conduct a series of comprehensive systematic reviews of randomised trials addressing specific questions in the use of chemotherapy and endocrine therapy in advanced breast cancer. Scope: The effectiveness of each treatment will be evaluated using survival, time to disease progression, quality of life and treatment toxicity when possible. A protocol is being developed for each review question which clearly states the methods of the review including data collection, inclusion criteria, critical appraisal and analysis. Every attempt is being made to identify and include the results of all randomised trials conducted in each question. The results of these reviews will enable patients and clinicians to make treatment decisions based on the best available evidence, and which balance the ability to achieve cancer control against factors such as treatment toxicity and quality of life. The reviews will also enable the researchers to identify areas in need of further research, as well as questions for which there are already clear answers and further research is unnecessary. Major findings: This project is currently underway and results are not yet available for any of the reviews.