Sulfur Mustard-induced Neutropenia: Treatment with Granulocyte Colony- stimulating Factor

摘要

Although best known as a blistering agent, sulfur mustard (HD) can also induce neutropenia in exposed individuals, increasing their susceptibility to infection. Granulocyte colony-stimulating factor (G-CSF) and pegylated G-CSF (peg-G-CSF) have been approved by the U.S. Food and Drug Administration as hematopoietic growth factors to treat chemotherapy-induced neutropenia. The goal of this study was to determine the effectiveness of G-CSF and peg-G-CSF in ameliorating HD-induced neutropenia. African green monkeys (Chiorocebus aethiops) were challenged with HD and, at 1, 3, 5, or 7 days after exposure, G- CSF therapy (10 microgram/kg per day for 21 days) was initiated. Peg-G-CSF (300 microgram/kg, single treatment) was similarly tested, with treatment given at 3 days after exposure. Untreated HD-exposed animals recovered from neutropenia 28 days after exposure. whereas G-CSF- or peg-G-CSF-treated animals recovered 8 to 19 days after exposure.