The Relationship among

摘要

Microporous membrane filtration is the technique often applied to the aseptic processing of drug preparations. This is especially appropriate when the ingredients are heat labile. Certain filter performance qualities are of specific interest in such filtrations, namely, the extent of organism removal, the rate of liquid flow, and the total throughput volume. Essentially, it is the numbers and sizes of the pores relative to the number and sizes of suspended particles that determine the filter retention performance, although there are other factors that also affect organism removals (1). The total aggregate space of the pores within the solid filter matrix represents the membrane's porosity. It is constituted of the total number of pores of whatever dimensions. The importance of pore size is obvious. The filter pores are the sites through which the liquid flows. Simultaneously, its suspended particles, such as organisms, are retained at the pores. Ultimately, the throughput is limited by the accumulation of the particles at the pores causing their blockage.