Limited prognostic value of dual time point F-18 FDG PET/CT in patients with early stage (stage I & II) non-small cell lung cancer (NSCLC).

摘要

OBJECTIVE: The aim of the current study was to investigate the prognostic value of dual time point F-18 FDG PET/CT in patients with early stage (stage I & II) NSCLC. METHODS: A retrospective review identified 66 patients with surgically resected early (stage I & II) NSCLC who received dual time point F-18 FDG PET/CT at diagnosis of cancer. Survival analysis was conducted using Kaplan-Meier analysis, and survival curves stratified by age, sex, mediastinal lymph node involvement, TNM staging, SUV(maxE), SUV(maxD), and %DeltaSUV(max) were generated for estimation of overall survival and disease-free survival (DFS). Independent predictive factors for survival were determined using Cox proportional hazard model. RESULTS: The overall survival and DFS were better in patients with tumor SUV(maxE)/=5.75. Seventeen patients (18.2%) with a tumor SUV(maxD)>/=6.8 and 4 of 33 patients with tumor SUV(maxD)/=6.8 was 31.7 months and was significantly worse than the patients with tumor SUV(maxD)