Identification of methicillin-resistant or methicillin-susceptible Staphylococcus aureus in blood cultures and wound swabs by GeneXpert.

摘要

Until a decade ago, clinicians could use epidemiological clues to select empirical therapy for methicillin-susceptible Staphylococcus aureus (MSSA) or methicillin-resistant S. aureus (MRSA) (5). The emergence of MRSA as a community pathogen and the documentation of the inferiority of non-beta-lactam antibiotics in treating MSSA bacteremia greatly complicate initial antibiotic choice (2-4, 7, 8, 9). Early identification and determination of antibiotic susceptibility might help focus initial antibiotic therapy. We compared a multiplex PCR that identifies MSSA and MRSA to standard microbiologic techniques for evaluating the results of blood cultures (BCs) and wound swab (WS) cultures.