Pregnancy and Lung Transplantation

摘要

Purpose of Review In this article, we review the impact of pregnancy in lung transplant recipients. Specifically, we discuss maternal, fetal, and allograft outcomes. Furthermore, we highlight important considerations for management of pregnancy in these patients. Recent Findings Improved survival after lung transplantation means more women of childbearing age; many of them with cystic fibrosis may be able to consider pregnancy. Despite the high number of live births, these pregnancies remain at risk for hypertensive disorders, graft rejection, postpartum graft loss, preterm birth, maternal, and neonatal mortality. Furthermore, data on the fetal effects of standard immunosuppressive regimens used in lung transplant recipients is lacking. A detailed discussion regarding these complications and gaps in knowledge is critical during pre-pregnancy counseling. Despite these hurdles, carefully planned pregnancies with close monitoring and management by multidisciplinary teams can be successful. In selected patients, planned pregnancy after lung transplantation, albeit high risk for maternal and fetal complications, is feasible.