Palladium-Catalyzed Sequential Formation of C-C Bonds: Efficient Assembly of 2-Substituted and 2,3-Disubstituted Quinolines

摘要

Transition-metal-catalyzed transformations are attractive methodologies for the synthesis of heterocyclic compounds, and enable the direct formation of complicated molecules from readily accessible starting materials under mild conditions."' The outstanding potential of palladium-catalyzed processes lies 1) in the diversity of available bond-forming processes, such as C-C, C-O, and C-N bond forming, 2) in the excellent chemo-, regio-, and stereoselectivity that is generally observed, and 3) in their great functional-group tolerance. Besides, palladium-catalyzed processes constitute an efficient strategy to synthesize an increasingly wide range of polyfunctionalized compounds.