Repeating low-positive nucleic acid amplification test results for Chlamydia trachomatis and Neisseria gonorrhoeae: Assessment of current practice in selected California public- and private-sector laboratories

摘要

Routine repeat testing of specimens with a low-positive result for Chlamydia trachomatis and Neisseria gonorrhoeae by nucleic acid amplification test (NAAT) is not recommended (5) because of the following, (i) The majority of positive specimens that are negative on confirmatory testing are true positives, (ii) Infected patients will go untreated. In August 2010, the Centers for Disease Control and Prevention (CDC) disseminated a Laboratory Outreach Communication System (LOCS) advisory specifying that low-positive NAAT results should be reported as positive (3). In September 2010, we conducted a follow-up online survey of licensed laboratories respondents to the 2007 California Clinical Laboratory Survey (2) that reported routine repeat testing of specimens with low-positive C. trachomatis and N. gonorrhoeae NAAT results.