No Contribution of an Inductive Effect to Secondary Deuterium Isotope Effects on Acidity

摘要

Isotope effects are observed when a reaction rate or equilibrium constant changes as a result of isotopic substitution. They continue to be used as valuable tools to provide insight into molecular structure and reactivity. Secondary isotope effects are those in which the bond to the isotope remains intact. Their origin continues to be an area of investigation. Herein we address the origin of secondary deuterium isotope effects on acidity.