Total Syntheses of (-)-Scabronines G and A, and (-)-Episcabronine A

摘要

(-)-Scabronines A-G (Figure 1) and (-)-episcabronine A (2) were isolated from the bitter mushroom, Sarcodon scabrosus, and characterized by Ohta et al. (-)-Scabroni-ne A (1) contains six contiguous stereogenic centers in its seven-membered ring, thus distinguishing it as the most complex structure in the scabronine family. (-)-Scabronine G (3) possesses the least oxidized seven-membered ring of known scabronines, which range in oxidation state between 1 and 3. Biogenetic deviation of 1 from 3 through various oxidation processes is inferred by the array of isolated natural products.