Most Escherichia coli infections other than gastrointestinal infections are believed to originate from human fecal flora, and the term "extraintestinal pathogenic Escherichia coli" (ExPEC) was introduced to describe these E. coli strains (13). However, there is an enormous diversity of strains within the species E. coli, making it difficult to clearly identify the potential ExPEC strains among the gut E. coli isolates from healthy people by any simple measure.
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