Helicobacter pylori vacA as marker for gastric cancer and gastroduodenal diseases: One but not the only factor

摘要

We read with interest the recent article by Memon et al. (1). In this study involving the Belgian population, the Helicobacter pylori vacuolating cytotoxin (vacA) genotype was shown to be a strong marker for gastric cancer and duodenal ulcer disease. The finding that certain H. pylori vacA-positive strains are associated with key clinical outcomes is important, but available data are unfortunately contradictory.