Identification of a C2 subgenogroup strain of enterovirus 71 in a retrospective study in Shandong Province, China, from 1990 to 2010

摘要

Human enterovirus 71 (EV71) is an important pathogen and it can cause hand, foot, and mouth disease (HFMD), herpan-gina, and severe neurological symptoms. There was no intensive surveillance of EV71 until May 2008, when HFMD was classified as a category C notifiable infectious disease by the Ministry of Health of China (6). Acute flaccid paralysis (AFP) surveillance, developed for the polio eradication program, can obtain nonpolio enterovirus (NPEV) isolates as a side benefit. Here, we report the identification of EV71 isolated from AFP cases in 1990 to 2010.