Oxidation of Chloride and Subsequent Chlorunation of Organic Compounds by OxoIron(IV) Porphyrin π-Cation Radicals

摘要

Chloroperoxidase (CPO) and myeloperoxidase (MPO) are the only heme peroxidases that catalyze oxidation of the chloride ion (Cl") with hydrogen peroxide. CPO is an enzyme from Caldariomyces fumago and catalyzes chlorina-tion reactions in the biosynthesis of chlorine-containing compounds. CPO is also known to exhibit peroxidase, catalase, and cytochrome-P450-like activities. CPO has a thiolate heme axial ligand like cytochrome P450. This makes CPO distinct from other heme peroxidases which have a histidine imidazole as the heme axial ligand.